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Nadjet Lebsir

Associate Professor at UCLy

Research group (7) Biotechnologies, health and ethics

nlebsir@univ-catholyon.fr

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Function

  • Biology Lab manager, ESTBB Lyon Catholic University
  • Teacher, ESTBB Lyon Catholic University
  • Faculty researcher, Research Group 7 - Biotechnology, health and ethics Lyon Catholic University

Further information

Research areas

Virology Molecular biology cell biology infectious diseases viral hepatitis Cancerology virus-induced carcinogenesis hepatic virology hepatotropic viruses

Teaching areas

Molecular Biology Cell biology Virology Human physiology Biolotechnology Genetic Cell engineering Cellular technologies Principles of genetic analysis Genetic mechanisms virus-induces carcinogesis

Presentation

I am an associate-professor, specializing in hepatitis virology and liver carcinogenesis. I am affiliated with research group 7 of UR CONFLUENCE: Sciences and Humanities (EA1598) and with the ESTBB School of Biology and Biotechnology (UCLy).
My research is structured around two complementary and well-established axes:
- a mechanistic axis, focused on the effects of the viral protein HBx on hepatic cells;

- an international epidemiological axis, developed in collaboration with clinician-scientists in West Africa, addressing chronic HBV carriage and its associated risk factors.
I teach molecular and cellular biology, human physiology, and genetics, integrating theoretical foundations, experimental approaches, and contemporary issues in biosciences, health, and biotechnology, while guiding students toward informed scientific practices aligned with principles of sustainability.
I am also a lab manager and coordinator of the biology teaching laboratories within the Science Division (Pôle Sciences). This role includes monitoring the experimental spaces and facilities, managing equipment and supplies, ensuring regulatory compliance, and training new users, thereby maintaining high standards of safety and optimal conditions for teaching activities.
  • Scientific Publications & Communications
    • Articles In Peer-Reviewed Journals
      • LEBSIR, Nadjet, ZOULIM, Fabien, GRIGOROV, Boyan (2023). «Heparanase-1: From Cancer Biology to a Future Antiviral Target». Viruses, 15, 1, 237. [+]
      • GALLARD, Christophe, LEBSIR, Nadjet, KHURSHEED, Hira, REUNGOAT, Emma, PLISSONNIER, Marie-Laure, BRÉ, Jennifer, MICHELET, Maud, CHOUIK, Yasmina, ZOULIM, Fabien, PÉCHEUR, Eve-Isabelle, BARTOSCH, Birke, GRIGOROV, Boyan (2022). «Heparanase-1 is upregulated by hepatitis C virus and favors its replication». Journal of hepatology, 77, 1, 29-41. [+]
      • LEBSIR, Nadjet, GOUESLAIN, Lucie, FARHAT, Rayan, CALLENS, Nathalie, DUBUISSON, Jean, JACKSON, Catherine L., ROUILLÉ, Yves (2019). «Functional and Physical Interaction between the Arf Activator GBF1 and Hepatitis C Virus NS3 Protein». Journal of virology, 93, 6. [+]
      • FARHAT, Rayan, ANKAVAY, Maliki, LEBSIR, Nadjet, GOUTTENOIRE, Jérôme, JACKSON, Catherine L., WYCHOWSKI, Czeslaw, MORADPOUR, Darius, DUBUISSON, Jean, ROUILLÉ, Yves, COCQUEREL, Laurence (2018). «Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication». Cellular Microbiology, 20, 1, e12804. [+]
    • Presentations at Symposiums
      • Posters
        • LEBSIR, Nadjet, COLE , Laura, SEURRE , Coline. «Hepatitis B virus-related carcinogenesis in West Africa: Elucidating the cancer hallmarks induced by genotype E HBx protein». HBV international meeting 2025, HBV foundation, September 2025, Berlin, Germany.
        • LEBSIR, Nadjet, COLE, Laura, GORMALLY, Emmanuelle, LAWRENCE, Philip. «Carcinogenèse liée au virus de l’hépatite B en Afrique de l’Ouest : élucidation des hallmarks du cancer induits par la protéine HBx du génotype E». XXVIIes Journées Francophones de Virologie, Société Française de Virologie ; revue Virologie ; ENS Lyon, April 2025, Lyon, France.
        • LEBSIR, Nadjet, BALLARD , Christophe, ZAWWAT, Hira, REUNGOAT, Emma, BEARD, Nicolas, ZOULIM, Fabien, PECHEUR, Eve-Isabelle, BARTOSCH, Birke, GRIGOROV, Boyan. «Heparanase is upregulated by HCV and favors its replication». Réunion annuelle AC42 Réseau national des hépatites, ANRS, February 2020, Paris, France.
        • LEBSIR, Nadjet, GOUESLAIN, Lucie, FARHAT, Rayan, PENIN, François , DUBUISSON, Jean, JACKSON, Catherine L., ROUILLÉ, Yves. «Refined mapping of GBF1–HCV interaction dynamics». Journée francophones de virologie, Société française de virologie, February 2018, Paris, France.
        • LEBSIR, Nadjet, GOUESLAIN, Lucie, FARHAT, Rayan, PENIN, François , DUBUISSON, Jean, JACKSON, Catherine L., ROUILLÉ, Yves. «Molecular Insights into GBF1–HCV Protein Interactions». Journées franophones de virologie, Société française de virologie, April 2017, Paris, France.
        • LEBSIR, Nadjet, GOUESLAIN, Lucie, FARHAT, Rayan, PENIN, François , DUBUISSON, Jean, JACKSON, Catherine L., ROUILLÉ, Yves. «Molecular Insights into GBF1–HCV Protein Interactions». 17ème Journée André Verbert ( colloque des doctorants), EGBSL de l'Université de Lille, March 2017, Lille, France.
        • LEBSIR, Nadjet, GOUESLAIN, Lucie, FARHAT, Rayan, PENIN, François , DUBUISSON, Jean, JACKSON, Catherine L., ROUILLÉ, Yves. «Exploring interactions between GBF1 and HCV proteins». Réunion annuelle AC42 Réseau national des hépatites virales, ANRS, February 2017, Paris, France.
        • ROUILLÉ, Yves, GOUESLAIN, Lucie, LEBSIR, Nadjet, FARHAT, Rayan, PENIN, François , DUBUISSON, Jean, JACKSON, Catherine L. «Exploring interactions between GBF1 and HCV proteins». HCV16, International Symposium on Hepatitis C Virus and Related Viruses, October 2016, Kyoto, Japan.
  • Scientific Collaborations
    • Member of research laboratories
      • Since 2020, Member of the Research group (7) Biotechnologies, health and ethics, UR CONFLUENCE : Sciences et Humanités (EA1598), UCLy, France
    • Involvement in scientific groups and learned societies
      • Since 2021, Membre élue du Conseil scientifique de l’UCLy
    • Involvement in subsidised research contracts
      • Member : Déterminants virologiques, environnementaux et socio-structurels du portage chronique du VHB/VHD et du risque de carcinome hépatocellulaire au Sénégal (régions de Kaolack et Kaffrine), ANRS, in partnership with USSEIN – Université du Sine-Saloum El Hadj Ibrahima Niass ; Hôpitaux et centres cliniques de Kaolack ; IHU-institut hospitalo-universitaire de Lyon
    • Involvement in collective research projects
      • Since 2023, , Senegal
      • Since 2021,
      • Since 2021, , Mali
  • Supervision of master's thesis
    • 2025 - 2025, Master's thesis, Virology, Microbiology, Parasitology and Infectiology, Université Paris-Saclay (ex Paris-Sud).
  • Research Evaluation Activities
    • Participation in selection committees and academic bodies
      • 2025 : Membre d’un comité d’audition pour le recrutement d’enseignants-chercheurs (UCLy, campagne 2025)
    • Member of thesis juries
      • Thesis Reviewer : Elodie JOB, Optimisation du contrôle microbiologique des eaux pharmaceutiques : validation du REDBERRY comme alternative aux méthodes conventionnelles pour le bioburden et la stérilité, Master's thesis, Lyon Catholic University, Lyon, France, 10/11/2025
      • Thesis Reviewer : Emilie BENAT, Sécurisation des matières premières critiques chez BioMérieux : gestion du changement fournisseur et évaluation de nouvelles sources biologiques, Master's thesis, Lyon Catholic University, Lyon, France, 10/11/2025
      • Thesis Reviewer : Aurélie PERETTI, Rôle des métabolites du microbiote cutané dans la modulation de l’inflammation et de la régénération : approches en cultures bactériennes et co-cultures cellulaires pour applications dermo-esthétiques, Master's thesis, Lyon Catholic University, Lyon, France, 10/09/2025
      • Thesis Reviewer : Pauline CIAMPI, Optimisation de l’expression transgénique dans des vecteurs AAV produits en système baculovirus : comparaison de promoteurs pour une application en santé vétérinaire, Master's thesis, Lyon Catholic University, Lyon, France, 10/09/2025
      • Thesis Reviewer : Lucie COMPERE, Standardisation et harmonisation des processus de gestion de projets et de biobanking au sein d’Eurofins Biomnis Sample Library, Master's thesis, Lyon Catholic University, Lyon, France, 28/08/2025
      • Thesis Reviewer : Diane ATTANASIO, Amélioration des processus de production et de gestion des stocks dans une entreprise de génie tissulaire spécialisée en greffons osseux et membranaires, Master's thesis, Lyon Catholic University, Lyon, France, 11/09/2024
      • Thesis Reviewer : Paule-Martine COUSSOUD BEATRIX, Physiopathologie du vitiligo et évaluation des approches thérapeutiques proposées par ISISPharma, Master's thesis, Lyon Catholic University, Lyon, France, 11/09/2024
      • Thesis Reviewer : Clara KOUAKOU, Financial sustainability in Danish biobank, Master's thesis, Lyon Catholic University, Lyon, France, 28/08/2024
      • Thesis Reviewer : Adrien GREGORIO, Expression transitoire et activité biologique d’un adjuvant vaccinal, Master's thesis, Lyon Catholic University, Lyon, France, 14/09/2022
      • Thesis Reviewer : Bérénice JOYET, Développement de méthode et de procédures opérationnelles normalisées pour Elispot B chez Active Biomarkers, Master's thesis, Lyon Catholic University, Lyon, France, 14/09/2022
      • Thesis Reviewer : Pauline BRUN, Criblage de molécules antivirales sur les virus de la grippe, Master's thesis, Lyon Catholic University, Lyon, France, 14/09/2022
    • Reviewer of Scientific Publications
      • Since 2023, Reviewer of scientific publications, PLoS ONE
      • Since 2022, Review Editor in Frontiers Virus and Host
  • Scientific valorisation and dissemination of knowledge
    • Participation in expert bodies or committees, juries
      • Since 2023, Co-pilote du dispositif de formation Hygiène & Sécurité pour les nouveaux entrants (Pôle Sciences)
      • Since 2022,
  • Diplomas
    • 2018, Doctorat (PhD) en Aspects moléculaires et cellulaires de la biologie, Etude de l'interaction du facteur cellulaire GBF1 et des protéines virales du virus de l'hépatite C, Université de Lille, France
    • 2014, Master en Immunologie et maladies infectieuses, Université Toulouse III - Paul Sabatier, France
    • 2011, Master en immunotechnologie, Université d'Oran 1, Algérie
  • Research professional experiences
    • Since 2020, Faculty researcher, Research Group 7 - Biotechnology, health and ethics, UCLy, France
    • 2019 - 2020, Temporary Teaching and Research Assistant, Centre de Recherche en Cancérologie de Lyon (CRCL, UMR Inserm 1052 – CNRS 5286 – Centre Léon Bérard), France
  • Pedagogical activities and responsabilities
    • Since 2021, Teacher, ESTBB, UCLy, France
    • 2019 - 2020 Temporary Teaching and Research Assistant, Université Claude Bernard Lyon 1, France
    • Teaching
      • Since 2024, Cell Engineering, Lyon Catholic University, France
      • Since 2022, Introduction à l'analyse génétique, ESTBB, Lyon Catholic University, France
      • 2020 - 2023, cell culture, ESTBB, Lyon Catholic University, France
      • 2020 - 2022, Entreprise à 360°, ESTBB, Lyon Catholic University, France
      • 2020 - 2022, Immunologie appliquée au diagnostic, ESTBB, Lyon Catholic University, France
      • Since 2020, Genetic engineering, ESTBB, Lyon Catholic University, France
      • Since 2020, Genetic, ESTBB, Lyon Catholic University, France
      • Since 2020, Human Physiology (License then Bachelor's degree), ESTBB, Lyon Catholic University, France
      • Since 2020, cellular technologies, ESTBB, Lyon Catholic University, France
      • 2019 - 2020, Cancérologie TD, Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP Cancérologie ( M1 Cancer), Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP coordonnés Infectieux-Respiratoire-Digestif, Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, , Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP en Biophysique, Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, Practical courses in biotechnologies, Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP en bactériologie (2ème année Pharmacie), Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP en bactériologie (3A pharmacie), Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP en biochimie métabolique et structurale, Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP en bureatiqye (2A pharmacie), Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP en infectiologie virale (5A Pharmacie), Institut des Sciences Pharmaceutiques et Biologiques, France
      • 2019 - 2020, TP mycoses cutanées (3A pharmacie), Institut des Sciences Pharmaceutiques et Biologiques, France
  • Other Professional Experience
    • Since 2022, Biology Lab manager, ESTBB, UCLy, France
  • Awards and distinctions
    • 2021, Review Editor for the journal of Frontiers in Cellular and Infection Microbiology (Virus and Host), Frontiers in Cellular and Infection Microbiology, Suisse
    • 2020, Qualified by the French National University Council (CNU) – Sections 87, Conseil national des universités (CNU), France
    • 2020, Qualified by the French National University Council (CNU)- Sections 64 biochemistry and molecular biology, Conseil national des universités (CNU), France
    • 2018 - 2018, ANRS doctoral extension grant (3 months) supporting completion of PhD research and dissertation., ANRS Maladies infectieuses émergentes, France
    • 2015 - 2018, National doctoral fellowship competition: 6th place nationwide, Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation (MESRI), France
  • Certificates and training
    • Since 2025 Dangerous Goods Transport (TMD) certification-DEKRA, DEKRA, France
    • 2025 Locculus bioreactor training, GETINGE Applikon, Pays-Bas
    • Since 2024 CO₂ handling and safety training, Air Liquide healthcare, France
    • Since 2022 Autoclave operation and sterilization safety, Etudes Services Maintenance Médicale (ESMM), France
    • Since 2022 Leadership & Team Management training- Schiller & Mertens, Schiller & Mertens, Allemagne
    • 2020 Moodle training (digital pedagogy and learning platforms), UCLy, France
    • Since 2015 BSL-3 certification, Institut Pasteur de Lille, France
  • Languages
    • French - Able to teach
    • English - Able to teach
    • Arabic - Able to teach
    • Italian