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Thanh Nhat Pham

Associate Professor at UCLy

7. Biosciences, Technologies and Ethics

tnpham@univ-catholyon.fr

Campus Lyon - Saint Paul
10 Place des archives 69002 Lyon

Function

  • Member of Biosciences, technologies, ethics research team, UR CONFLUENCE : Sciences et Humanités (EA 1598) Lyon Catholic University
  • Lecturer, ESTBB Lyon Catholic University

Further information

  • CNU section: 86. Pharmacy - Pharmaceutical sciences (n° 17286298816)
  • ORCID: 0000-0002-6067-5806

Research areas

Biomass valorization Bioconversion Composé bioactif Biological evaluation Drug design

Teaching areas

General chemistry Biochemistry organic chemistry analytical chemistry Biotechnology

Presentation

Thanh-Nhat Pham obtained his Doctor of Pharmacy degree from University of Medicine and Pharmacy of Ho Chi Minh city (Vietnam; 2007-2012). He then studied a Master of Pharmaceutical Sciences at University of Lyon (France; 2012-2013), and a PhD in Life and Health Sciences at University of Bourgogne Franche-Comté (France; 2013-2016). His PhD work was on the research of new arginase inhibitors from natural sources and hemisynthesis, under direction of Prof. Corine Girard. He was Assistant Professor in Biochemistry and Medicinal Chemistry at Faculty of Pharmacy of Limoges (France; 2016-2017), where he worked with Prof. Bertrand Liagre on the evaluation of anticancer potentials of arginase inhibitors. Then, he joined the Faculty of Pharmacy, University of Picardie Jules Verne, Amiens (France; 2017-2018) as Assistant Professor in Medicinal Chemistry, and worked with Prof. Pascal Sonnet on the synthesis of siderophore-antimicrobial conjugates. He has been working as Associate Professor at Biology-Biochemistry-Biotechnologies School of the Lyon Catholic University (France) since 2018. His research interests focus on design, bio-synthesis and biological evaluation of new bioactive compounds from natural sources.
  • Scientific Publications & Communications
    • Articles In Peer-Reviewed Journals
      • ROBERTO DA SILVA, Edson, ABEL ALFREDO DOS SANTOS SIMONE COME, Júlio, BROGI, Simone, CALDERONE, Vincenzo, CHEMI, Giulia, CAMPIANI, Giuseppe, MARIA FERRREIRA DE SOUSA OLIVEIRA, Trícia, PHAM, Thanh Nhat, PUDLO, Marc, GIRARD, Corine, DO CARMO MAQUIAVELI, Claudia (2020). «Cinnamides Target Leishmania amazonensis Arginase Selectively». Molecules, 25, 22, 5271. [+]
      • BORDAGE, Simone, PHAM, Thanh Nhat, ZEDET, Andy, GUGGLIELMETTI, Anne-Sophie, DEMOUGEOT, Céline, GIRARD-THERNIER, Corine (2017). «Investigation of mammal arginase inhibitory properties of natural ubiquitous polyphenols by using an optimized colorimetric microplate assay». Planta Medica, 83, 7, 647-653. [+]
      • PHAM, Thanh Nhat, BORDAGE, Simone, PUDLO, Marc, DEMOUGEOT, Céline, THAI, Khac-Minh, GIRARD-THERNIER, Corine (2016). «Cinnamide derivatives as Mammals Arginase Inhibitors: Design, Synthesis, Molecular Docking and Biological Evaluation». International Journal of Molecular Sciences, 17, 10, 1656. [+]
    • Review Articles
      • CAZIER, Elisabeth A., PHAM, Thanh Nhat, COSSUS, Louis, ABLA, Maher, ILC, Tina, LAWRENCE, Philip (2024). «Exploring industrial lignocellulosic waste: Sources, types, and potential as high-value molecules». Waste Management, 188, 11-38. [+]
      • PHAM, Thanh Nhat, CAZIER, Elisabeth A., GORMALLY, Emmanuelle, LAWRENCE, Philip (2024). «Valorization of biomass polyphenols as potential tyrosinase inhibitors». Drug Discovery Today, 29, 1, 103843. [+]
      • PHAM, Thanh Nhat, LOUPIAS, Pauline, DASSONVILLE-KLIMPT, Alexandra, SONNET, Pascal (2019). «Drug delivery systems designed to overcome antimicrobial resistance». Medicinal research reviews, 39, 6, 2343-2396. [+]
      • PHAM, Thanh Nhat, LIAGRE, Bertrand, GIRARD-THERNIER, Corine, DEMOUGEOT, Céline (2018). «Research of novel anticancer agents targeting arginase inhibition». Drug Discovery Today, 23, 4, 871-878. [+]
      • GIRARD-THERNIER, Corine, PHAM, Thanh Nhat, DEMOUGEOT, Céline (2015). «The Promise of Plant-derived Substances as Inhibitors of Arginase». Mini-Reviews in Medicinal Chemistry, 15, 10, 798-808. [+]
    • Interventions In Symposiums
      • Communications in a symposium, scientific seminars
        • PHAM, Thanh Nhat, TRINH, Duc-Thu, BORDAGE, Simone, DEMOUGEOT, Céline, PUDLO, Marc, THAI, Khac-Minh, GIRARD-THERNIER, Corine (2016). «Synthèse, docking moléculaire et évaluation biologique de dérivés cinnamides à potentialités inhibitrices d’arginase mammifère». 22e Forum des jeunes chercheurs ED Environnement-Santé, UBFC, July 2016, Besançon, France.
        • PHAM, Thanh Nhat, BORDAGE, Simone, ZEDET, Andy, GUGGLIELMETTI, Anne-Sophie, NAPPEY, Maude, THAI, Khac-Minh, DEMOUGEOT, Céline, GIRARD-THERNIER, Corine (2016). «Evaluations in vitro et in silico de l’activité inhibitrice de polyphénols naturels sur l’enzyme arginase». Journée scientifique annuelle de la SFR FED, April 2016, Besançon, France.
        • PHAM, Thanh Nhat, GIRARD-THERNIER, Corine (2015). «Hemi-synthesis of plant-derived compounds as new arginase inhibitors». 1ère Rencontre Franco-Thai NATSAT : Enzymes, Targets for Plant-derived Compounds, PEPITE EA4267, Université de Franche-Comté, April 2015, Besançon, France.
      • Posters
        • SAVARINO, Baptiste, COSSOUD BEATRIX , Paule-Martine, CAZIER, Elisabeth A., GORMALLY, Emmanuelle, LAWRENCE, Philip, PHAM, Thanh Nhat (2023). «Valorisation of polyphenols from industrial black tea waste». XXXI International Conference on Polyphenols - ICP2023, INRAE & Groupe Polyphénols, July 2023, Nantes, France. [+]
        • PHAM, Thanh Nhat, TRINH, Duc-Thu, BORDAGE, Simone, DEMOUGEOT, Céline, PUDLO, Marc, THAI, Khac-Minh, GIRARD-THERNIER, Corine (2016). «Arginase Inhibitors: from chlorogenic acid to cinnamides». 9th Joint Natural Products Conference 2016, American Society of Pharmacognosy, Society for Medicinal Plant and Natural Product Research, Phytochemical Society of Europe, Società Italiana di Fitochimica, Ass. Francophone pour l’Ens. et la Rech. en Pharmacognosie, Japanese Society of Pharmacognosy, July 2016, Copenhague, Denmark.
        • PHAM, Thanh Nhat, BORDAGE, Simone, THAI, Khac-Minh, DEMOUGEOT, Céline, GIRARD-THERNIER, Corine (2015). «Cinnamides as potential arginase inhibitors». 7th International conference on Polyphenols and Health, Royal Society of Chemistry, October 2015, Tours, France.
        • PHAM, Thanh Nhat, NGUYEN, Thi Thu Ha, GIRARD-THERNIER, Corine, THAI, Khac-Minh, TRINH, Duc-Thu (2015). «Molecular docking study of some cinnamide derivatives as bovine arginase I inhibitors». 1st International conference on Pharmacy education and research network of ASEAN, ASEAN pharmacy schools, October 2015, Bangkok, Thailand.
        • PHAM, Thanh Nhat, TRINH, Duc-Thu, BORDAGE, Simone, DEMOUGEOT, Céline, PUDLO, Marc, THAI, Khac-Minh, GIRARD-THERNIER, Corine (2015). «Cinnamides as potential arginase inhibitors». 2nd International symposium AFERP-STOLON, AFERP-STOLON, Université de Lyon, July 2015, Lyon, France.
        • PHAM, Thanh Nhat, GUGLIELMETTI, Anne-Sophie, FIMBEL, Stéphane, DEMOUGEOT, Céline, GIRARD-THERNIER, Corine (2014). «Arginase inhibitory activity of several natural polyphenols using a novel in vitro test on purified arginase». 62nd International Congress and Annual Meeting, Society for Medicinal Plant and Natural Product Research (GA), July 2014. [+]
  • Scientific valorisation and dissemination of knowledge
    • Popular Science
      • Articles
        • FAOUZI, Abdelfattah , ARNAUD, Alexandre , HALLÉ, François , ROUSSEL, Jean , AYMARD, Mandy , DENAVIT, Vincent , DO, Cong Viet , MULARONI, Angélique , SALAH, Mohamed , ELHADY, Ahmed , PHAM, Thanh Nhat, BANCET, Alexandre, LE BORGNE, Marc , TERREUX, Raphaël , BARRET, Roland , ENGEL, Matthias , LOMBERGET, Thierry (2024). «Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors». RSC Medicinal chemistry, Online version of record. [+]
  • Scientific Collaborations
    • Member of research laboratories
      • Since 01/09/2020, Member of Biosciences, technologies, ethics research team, UR CONFLUENCE : Sciences et Humanités (EA 1598), UCLy, France
      • 2013 - 2016, Doctoral student in the PEPITE EA4267 research team, Université de Franche-Comté, France
    • Involvement in subsidised research contracts
      • Project coordinator : 01/01/2020 - 31/12/2024, Recovery of industrial by-products through biotechnological solutions, Val-Indus
  • Organisation Of Symposiums
    • Since 2024-06-13, Demi-journée scientifique "Comment mieux valoriser la biomasse végétale en région AURA ? ", Lyon Catholic University, France
    • 2016 : Member of the organisation committee for the scientific day of the young researchers of the Environment-Health doctoral school, University of Bourgogne-Franche-Comté (UBFC), France
  • Research stays
    • 01/09/2015 : Research Internship in Thailand, Thailand
    • 02/06/2014 : Research internship in Vietnam, Vietnam
  • Scientific valorisation and dissemination of knowledge
    • Organisation of scientific mediation events
      • 2023 : 70 ans de l'ESTBB, Atelier de recherche Grand Public : Processus de valorisation de la drêche de thé, ESTBB,, Lyon Catholic University, France
      • 2023 : , Lyon Catholic University, France
  • Diplomas
    • 2016, Docteur en Sciences de la vie et de la santé, Université de Franche-Comté, France
    • 2013, Master en Sciences du médicament, Université Claude Bernard Lyon 1, France
    • 2012, Docteur en Pharmacie, Université de pharmacie et médecine, Vietnam
  • Research professional experiences
    • Since 01/09/2020, Teacher-researcher, UCLy, France
    • 2017 - 2018, Post-doc in the AGIR team, Université Picardie Jules Verne Amiens (UPJV), France
    • 2016 - 2017, Post-doc in the PEIRENE team, Université de Limoges, France
    • 2013 - 2013, Research team member in EA4446, ISBP, Université de Lyon, France
  • Pedagogical activities and responsabilities
    • Since 2018, Lecturer, ESTBB, UCLy, France
    • Since 2017, Lecturer (ATER), Faculty of Pharmacy, Université Picardie Jules Verne Amiens (UPJV), France
    • Since 2016, Lecturer (ATER), faculty of pharmacy, Université de Limoges, France
    • Teaching
      • 2021 - 2023, Encadrement de plusieurs stagiaires participant aux travaux de recherche sur la valorisation de biomasse ( 2 apprentis 21-22 et 22-23), 1 stagiaire AI3 (stage de fin d’études, Formation d’Assistant-Ingénieur ESTBB), 2 stagiaires AI2 (Formation d’Assistant-Ingénieur ESTBB) et 1 stagiaire SVH3 (Licence Sciences de la Vie ESTBB), Lyon Catholic University, France
      • 2018 - 2019, Two training courses for medical laboratory trainers: Ministry of Health, Laos, University of Health Sciences, Cambodia
      • Since 2018, , Lyon Catholic University, France
      • 2017 - 2018, Chimie thérapeutique, Université Picardie Jules Verne Amiens (UPJV), France
      • 2016 - 2017, Chimie thérapeutique, Biochimie, Université de Limoges, France
      • 2014 - 2016, , Université de Franche-Comté, France
  • Awards and distinctions
    • 2015, Grand Prize of the "My thesis in 180s" contest, Université de Bourgogne, France
    • 2013 - 2016, Université de Franche-Comté, France
    • 2012 - 2013, Bourse de la Région Rhône-Alpes (MIRA), Université de Lyon (UDL), France
  • Languages
    • French - Capable d'enseigner
    • English - Capable d'enseigner